RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE OS CISTOS OVARIANOS EM VACAS Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 11. CISTOS OVÁRICOS Os cistos são cavidades anormais que às vezes possuem conteúdo de fluido biológico, ou podem ser cavidades ocas, com paredes sólidas refratárias à maioria dos compostos endógenos. Formam-se como alterações patológicas das células luteais ou foliculares do estroma ovárico. A presença de cistos altera o ciclo estral e obriga a (...) realização de tratamentos exógenos para remover o mesmo, fazendo com que a atividade cíclica da gônada retome sua normalidade (HATLER, et al. 2006). Alguns fatores de origem nutricional, tanto por deficiência de alguns compostos, como por excesso no fornecimento de outros, têm sido considerados como causas potenciais dos cistos, entre os principais fatores nutricionais podemos citar: 11.1 Fito-toxidade/fitoestrogênios Compostos vegetais, tais como plantas com elevado teor de flavonoides estrogênicos, encontram-se sob a forma de glicosídeos e têm a capacidade para modificar os processos reprodutivos devido à sua semelhança com os núcleos esteroides de hormônios femininos; são substâncias estruturais e funcionalmente semelhantes ao 17-ß-estradiol ou que produz efeitos estrogênicos (MENDOZA, et al. 2001). Pouco se sabe sobre os estrogênios presentes nas plantas e os níveis de fito-toxidade dos mesmos, logo na prática torna-se algo difícil de ser observado e atacado. Porém, a nível laboratorial, caso haja alguma complicação que afete o animal para além das capacidades reprodutivas, um diagnóstico aprofundado é o mais indicado. 11.2 Minerais 11.2.1 Iodo (I) Alimentos com baixo teor de iodo, provocam estros silenciosos nos animais e aumentam a incidência de quistos ováricos. O I é parte da molécula de tiroxina que estimula a produção de ATP na mitocôndria, a deficiência reduz a captação de oxigênio o que determina uma diminuição no metabolismo energético. Na tireoide existe um complexo de proteína-iodo, chamado tiroglobulina, essa molécula é uma glicoproteína. A maioria do I é reduzida a iodo inorgânico no trato gastrointestinal e a sua absorção é imediata. A função principal da tireoide é acumular I e fixá-lo, formando hormônios da tireoide sob o controle da adenohipófise por secreção (TSH). O I é convertido em iodeto no trato intestinal e então é transportado para a tireoide, aqui as células foliculares o prendem com efetividade através de um processo de transporte ativo, contra um gradiente de concentração, estimulado por TSH. Uma vez que as hormonas da tireoide controlam o metabolismo, uma deficiência em I diminui a taxa metabólica do organismo, isso afeta indiretamente a reprodução, uma vez que o funcionamento irregular da tireoide afeta a formação de lipídios, esses necessários para a produção de hormônios esteroides (estrogênios) e estes por sua vez influenciam a síntese das prostaglandinas F2-alfa necessária para o processo de luteólise o que faz com que o corpo lúteo não se rompa, perdure e forme um cisto. O I presente no alimento do animal deve estar presente e obedecer o intervalo de 0,34 a 0,88 mg/kg de MS em todos os alimentos que o animal viera a ingerir, seja forragens ou rações. A forma de suplementação são as mais conhecidas, via volumoso, concentrado, água ou pelo sistema SMI. 11.2.2 Manganês (Mn) Níveis elevados de manganês na dieta levam à depleção da absorção de ferro, bem como de outros minerais necessários para a síntese, metabolismo, ativação de enzimas e absorção de outros minerais. Essas interações com outros minerais e o papel do excesso de manganês na inibição da síntese dos precursores de hormonas necessárias para a reprodução, bem como dos metabolitos gerados durante o desdobramento ruminal são representados de forma indireta. Para além do efeito antagônico com outros minerais e enzimas, níveis elevados de manganês provocam uma alteração na população da flora ruminal, o que prejudica a produção de ácido propiônico e butírico a nível ruminal, tendo um efeito negativo no metabolismo dos lipídios com uma subsequente baixa de energia (derivado do metabolismo graxo diminuído ou inibido) e também da síntese de ácidos graxos. Por esta última razão, ocorre uma diminuição na síntese das hormonas esteroides, as quais, não estando presentes em níveis adequados, geram problemas no ciclo estral, uma vez que estas hormonas são essenciais para a síntese das prostaglandinas (PGF2-α) que são necessários para a lise do corpo lúteo, com sua posterior persistência, terminando na formação de um cisto luteal. Como sempre falado nos capítulos dessa compilação de trabalhos, o composto Mn é mais um mineral imprescindível para a alimentação do animal, manutenção normal dos seus mecanismos fisiológicos e relações com outros minerais. Sua disponibilidade para o animal deve ser de 12 a 50 mg/kg de MS das forragens, ou a mesma quantidade no conteúdo da ração balanceada. É um elemento que pode ser colocado na água para absorção pelos animais ou através da suplementação mineral injetável (SMI). 11.2.3 Sódio (Na) Os sinais de deficiência de Na são inespecíficos, mas os mais expressivos são sobre o crescimento e produção leiteira. Numa diminuição do consumo de Na, o organismo ativa os mecanismos de conservação mediados pela liberação de aldosterona que aumenta a reabsorção a nível dos túmulos renais deste mineral. A deficiência de Na afeta a produção de muco cervical, com consequências como problemas na formação de espermatozoides e aumento das infecções uterinas. Dado que a deficiência de Na é rara, apenas os sintomas clínicos desta deficiência mineral podem ser vagamente descritos é k caso da dificuldade de concepção, distorcias e bezerros fracos ao nascimento, além da inatividade ovárica e maior incidência de retenção de placenta. As causas de tais alterações foram motivo de numerosos estudos com resultados contraditórios, as vacas com deficiência de energia no início da amamentação têm diminuição nas concentrações de hormona luteinizante (LH), isto conclui que a alteração ovárica seria determinada por uma alteração da liberação pulsátil de LH devido a uma deficiência energética aguda. A intensidade e a duração do estro são de importância fundamental para a IA nos bovinos. Ao ocorrer uma deficiência de sódio, aumenta-se a estabilização das membranas celulares impedindo que o corpo lúteo se lise, formando-se um cisto, que continuará com a produção de progesterona, levando, por fim, a um anestro patológico. O sódio é um elemento que deve estar disponível aos animais de forma à vontade, ou seja, esse mineral é combinado com o Cl, fazendo o balanceamento eletrolítico e disponibilizado para os animais pelo conhecido sal. Sua administração, como é em sistema à vontade, não é muito controlada, mas o produtor poderá fornecer as quantidades na mistura alimentar do animal, tendo um maior controle da absorção do mesmo pelos animais. Sendo assim, o Na deve ser fornecido em quantidades que obedeçam 0,10 a 0,18% da MS no caso das forrageiras, ou a mesma quantidade misturada no todo da ração, quantidade essa encontrada por meios de cálculos, ou que já vêm na composição da ração industrial. Estudos apontam que um animal deve ingerir cerca de 50 gramas de NaCl por dia, no caso do sódio estar presente em 39% da composição desse cloreto de sódio. REFERÊNCIAS BIBLIOGRÁFICAS BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. CHAMBA OCHOA, Hermógenes René; BENÍTEZ GONZÁLEZ, Edgar Enrique; PESÁNTEZ CAMPOVERDE, Manuel Teodoro. Factores predisponentes para la enfermedad quística ovárica bovina y su efecto en la eficiencia reproductiva. Revista de Medicina Veterinaria, v. 1, n. 35, p. 17-28, 2017. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. FERNANDES, C. A. C. et al. Fatores predisponentes para cistos ovarianos em vacas da raça holandesa. Ars Veterinaria, v. 21, n. 2, p. 287-296, 2008. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. HATLER, T. B. et al. Effect of a single injection of progesterone on ovarian follicular cysts in lactating dairy cows. The Veterinary Journal, v. 172, n. 2, p. 329-333, 2006. KESLER, D. J.; GARVERICK, H. A. Ovarian cysts in dairy cattle: a review. Journal of animal science, v. 55, n. 5, p. 1147-1159, 1982. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. MENDOZA, R. Muñoz et al. Parámetros reproductivos en vacas Holstein alimentadas con alfalfa alta en cumestrol. Archivos de zootecnia, v. 51, n. 195, p. 373-376, 2002. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. SARTORI, Roberto; GUARDIEIRO, Monique Mendes. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. THATCHER, W. W. et al. Strategies for improving fertility in the modern dairy cow. Theriogenology, v. 65, n. 1, p. 30-44, 2006. TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. YOSHIOKA, Koji; IWAMURA, Shokichi; KAMOMAE, Hideo. Changes of ovarian structures, plasma LH, FSH, progesterone and estradiol-17β in a cow with ovarian cysts showing spontaneous recovery and relapse. Journal of veterinary medical science, v. 60, n. 2, p. 257-260, 1998. (shrink)

In 1969 Harry Frankfurt published his hugely influential paper 'Alternate Possibilities and Moral Responsibility' in which he claimed to present a counterexample to the so-called 'Principle of Alternate Possibilities' ('a person is morally responsible for what he has done only if he could have done otherwise'). The success of Frankfurt-style cases as counterexamples to the Principle has been much debated since. I present an objection to these cases that, in questioning their conceptual cogency, undercuts many of those debates. Such cases (...) all require a counterfactual mechanism that could cause an agent to perform an action that he cannot avoid performing. I argue that, given our concept of what it is for someone to act, this requirement is inconsistent. Frankfurt-style alleged counterexamples are cases where an agent is morally responsible for an action he performs even though, the claim goes, he could not have avoided performing that action. However, it has recently been argued, e.g. by John Fischer, that a counterexample to the Principle could be a 'Fischer-style case', i.e. a case where the agent can either perform the action or do nothing else. I argue that, although Fischer-style cases do not share the conceptual flaw common to all Frankfurt-style cases, they also fail as counterexamples to the Principle. The paper finishes with a brief discussion of the significance of the Principle of Alternate Possibilities. (shrink)

In this paper I propose a way of characterizing human agency in terms of the concept of a two‐way power. I outline this conception of agency, defend it against some objections, and briefly indicate how it relates to free agency and to moral praise‐ and blameworthiness.

Ignorance is often a perfectly good excuse. There are interesting debates about whether non-culpable factual ignorance and mistake subvert obligation, but little disagreement about whether non-culpable factual ignorance and mistake exculpate. What about agents who have all the relevant facts in view but fail to meet their obligations because they do not have the right moral beliefs? If their ignorance of their obligations derives from mistaken moral beliefs or from ignorance of the moral significance of the facts they have in (...) view, should they be excused for failing to meet their moral obligations? It is not obvious that they should. In this paper we argue that the best non-skeptical accounts of moral responsibility acknowledge that factual ignorance and mistake will diminish moral responsibility in a way that moral ignorance and mistake will not. That is because factual ignorance is often non-culpable so long as it meets certain merely procedural epistemic standards but the same is not true of moral ignorance. Our argument is that the assumption that it is gets the standards of culpability for moral ignorance wrong, and that the mistake is encouraged by the thought that culpability in general requires an instance of known wrongdoing: that acting wrongly requires de dicto unresponsiveness to one’s obligations at some stage. We deny this and conclude that, therefore, ignorance and mistaken belief are indeed often perfectly good excuses – but far less often than some philosophers claim. (shrink)

This paper discusses the logical space of alternative conceptual engineering projects, with a specific focus on (1) the processes, (2) the targets and goals, and (3) the methods of such projects. We present an overview of how these three aspects interact in the contemporary literature and discuss those alternative projects that have yet to be explored based on our suggested typology. We show how choices about each element in a conceptual engineering project constrain the possibilities for the others, thereby giving (...) rise to distinct groupings of possible projects under the banner of conceptual engineering. We conclude with a critical reflection on the potential ethical issues that arise as a result of effectively putting conceptual engineering into practice. (shrink)

Reasons can play a variety of roles in a variety of contexts. For instance, reasons can motivate and guide us in our actions (and omissions), in the sense that we often act in the light of reasons. And reasons can be grounds for beliefs, desires and emotions and can be used to evaluate, and sometimes to justify, all these. In addition, reasons are used in explanations: both in explanations of human actions, beliefs, desires, emotions, etc., and in explanations of a (...) wide range of phenomena involving all sorts of animate and inanimate substances. This diversity has encouraged the thought that the term 'reason' is ambiguous or has different senses in different contexts. Moreover, this view often goes hand in hand with the claim that reasons of these different kinds belong to different ontological categories: to facts (or something similar) in the case of normative/justifying reasons, and to mental states in the case of motivating/explanatory reasons. In this paper I shall explore some of the main roles that reasons play and, on that basis, I shall offer a classification of kinds of reasons. As will become clear, my classification of reasons is at odds with much of the literature in several respects: first, because of my views about how we should understand the claim that reasons are classified into different kinds; second, because of the kinds into which I think reasons should be classified; and, finally, because of the consequences I think this view has for the ontology of reasons. (shrink)

Translation of Aristotle's Physics I-II into Portuguese, with commentaries. Tradução para o português dos livros I e II da Física de Aristóteles, com comentários.

Evolutionary aesthetics (EA) investigates the origins and evolution of aesthetic preferences and artistic behaviors, along with the underlying capacities that support these preferences and behaviors. EA is a multidisciplinary approach that intersects various disciplines – e.g. evolutionary psychology, biology, neurosciences, art history, archeology, anthropology, philosophical aesthetics – providing a comprehensive framework for understanding the deep-rooted biological and evolutionary underpinnings of human aesthetic preferences and artistic expressions. Central to EA, in fact, is the exploration of when, how and why aesthetic preferences (...) and artistic behaviors originated in human history, as well as understanding whether these behaviors are evolutionary adaptations, by-products of evolutionary processes, or nonbiological cultural products (Killin 2021; Richards 2022). (shrink)

I discuss in this paper the six requirements Aristotle advances at Posterior Analytics A-2, 71b20-33, for the premisses of a scientific demonstration. I argue that the six requirements give no support for an intepretation in terms of “axiomatization”. Quite on the contrary, the six requirements can be consistently understood in a very different picture, according to which the most basic feature of a scientific demonstration is to explain a given proposition by its appropriate cause.

Two conceptions of motivating reasons, i.e. the reasons for which we act, can be found in the literature: (1) the dominant 'psychological conception', which says that motivating reasons are an agent's believing something; and (2) the 'non-psychological' conception, the minority view, which says that they are what the agent believes, i.e. his beliefs. In this paper I outline a version of the minority view, and defend it against what have been thought to be insuperable difficulties - in particular, difficulties concerning (...) 'error cases' (cases where what the agent believes is false); and difficulties concerning the explanation of action. Concerning error cases, I argue that if we are motivated by something believed that is true, what motivates us to act is a motivating reason. By contrast, if we are motivated by something believed that is false, then what motivates us to act is merely an apparent motivating reason. Either way, what motivates us is, as the non-psychological conception says, what we believe and not our believing it. I offer an account of the relation between motivating reasons and the explanation of action, and argue that this account helps bring out two important points. One is that the fact that we often do, and indeed sometimes must, use explanations such as 'He did it because he believed that p' does not vindicate the psychological conception of motivating reasons. The other is that endorsing the non-psychological conception of motivating reasons does not commit one to a non-factive view of explanations of action. (shrink)

Conceptual engineering is the method for assessing and improving our concepts. However, little has been written about how best to conceive of concepts for the purposes of conceptual engineering. In this paper, I aim to fill this foundational gap, proceeding in three main steps: First, I propose a methodological framework for evaluating the conduciveness of a given concept of concept for conceptual engineering. Then, I develop a typology that contrasts two competing concepts of concept that can be used in conceptual (...) engineering — namely, the philosophical and psychological ones. Finally, I evaluate these two concepts of concept using the proposed methodological framework and I show that, when it comes to making conceptual engineering an actionable method, the psychological concept of concept outclasses its philosophical counterpart on all counts. This provides a baseline from which the concept of concept can be further improved for the purposes of conceptual engineering. (shrink)

Conceptual engineering means to provide a method to assess and improve our concepts working as cognitive devices. But conceptual engineering still lacks an account of what concepts are (as cognitive devices) and of what engineering is (in the case of cognition). And without such prior understanding of its subject matter, or so it is claimed here, conceptual engineering is bound to remain useless, merely operating as a piecemeal approach, with no overall grip on its target domain. The purpose of this (...) programmatic paper is to overcome this knowledge gap by providing some guidelines for developing the theories of concepts and of cognition that will ground the systematic unified framework needed to effectively implement conceptual engineering as a widely applicable method for the cognitive optimization of our conceptual devices. (shrink)

We discuss a well-known puzzle about the lexicalization of logical operators in natural language, in particular connectives and quantifiers. Of the many logically possible operators, only few appear in the lexicon of natural languages: the connectives in English, for example, are conjunction _and_, disjunction _or_, and negated disjunction _nor_; the lexical quantifiers are _all, some_ and _no_. The logically possible nand (negated conjunction) and Nall (negated universal) are not expressed by lexical entries in English, nor in any natural language. Moreover, (...) the lexicalized operators are all upward or downward monotone, an observation known as the Monotonicity Universal. We propose a logical explanation of lexical gaps and of the Monotonicity Universal, based on the dynamic behaviour of connectives and quantifiers. We define update potentials for logical operators as procedures to modify the context, under the assumption that an update by \( \phi \) depends on the logical form of \( \phi \) and on the speech act performed: assertion or rejection. We conjecture that the adequacy of update potentials determines the limits of lexicalizability for logical operators in natural language. Finally, we show that on this framework the Monotonicity Universal follows from the logical properties of the updates that correspond to each operator. (shrink)

ABSTRACT (ITA) Un’idea emerge, si sviluppa, guadagna consenso, muta, talvolta scompare per poi risorgere. Questo è anche stato il destino dell’idea di evoluzione, il cui lungo cammino viene ricostruito in questo saggio, dai Greci fino ai nostri giorni. A partire dal diciassettesimo secolo questa nozione assume sempre più rilevanza nello studio della natura. In ciascun pensatore l’idea di un’evoluzione delle specie viventi è stata accompagnata da una teoria volta a spiegare le cause e il meccanismo del mutamento. Questo saggio racconta (...) non soltanto la genesi e lo sviluppo dell’idea tout court che la natura in qualche modo si trasformi, ma anche la storia delle teorie che, assumendo come reale questa trasformazione, ne postulano una spiegazione. Particolare attenzione viene data ad alcuni aspetti spesso trascurati che hanno reso possibile il concetto di evoluzione del mondo vivente come la conosciamo adesso, di cui se ne mostra la rilevanza, già a partire dal pensiero greco. -/- ABSTRACT (ENG) An idea emerges, develops, gains consensus, evolves, sometimes disappears and then rises again. This was also the fate of the idea of evolution, whose long journey is reconstructed in this essay, from the Greeks to the present day. Since the seventeenth century, this idea has become more and more relevant in the study of nature. In each thinker the idea of an evolution of living species has been accompanied by a theory aimed at explaining the causes and the mechanism of change. This essay tells not only the genesis and development of the idea that nature somehow transforms itself, but also the history of the theories which, assuming this transformation as real, postulate an explanation. Particular emphasis is given to some often overlooked aspects that made possible the concept of evolution of the living world as we know it now, whose full relevance is shown, starting from Greek thought. Keywords: evolution, natural selection, Charles Darwin, history of ideas, history of science. (shrink)

Tradução preliminar em pré-print. A Tradução definitiva é a de 2009.

Experiences like pains, pleasures, and emotions have affective phenomenal character: they feel pleasant or unpleasant. Imperativism proposes to explain affective phenomenal character by appeal to imperative content, a kind of intentional content that directs rather than describes. We argue that imperativism is on the right track, but has been developed in the wrong way. There are two varieties of imperativism on the market: first-order and higher-order. We show that neither is successful, and offer in their place a new theory: reflexive (...) imperativism. Our proposal is that an experience P feels pleasant in virtue of being constituted by a Command with reflexive imperative content, while an experience U feels unpleasant in virtue of being constituted by a Command with reflexive imperative content : More of P!Less of U! If you need a slogan: experiences have affective phenomenal character in virtue of commanding us Get more of me! Get less of me! (shrink)

This paper seeks a better understanding of the elements of practical reasoning: premises and conclusion. It argues that the premises of practical reasoning do not normally include statements such as ‘I want to ϕ’; that the reasoning in practical reasoning is the same as in theoretical reasoning and that what makes it practical is, first, that the point of the relevant reasoning is given by the goal that the reasoner seeks to realize by means of that reasoning and the subsequent (...) action; second, that the premises of such reasoning show the goodness of the action to be undertaken; third, that the conclusions of such reasoning may be actions or decisions, that can be accompanied by expressions of intention, either in action, or for the future; and that these are justified, and might be contradicted, in ways that are not only peculiar to them (i.e. in ways that diverge from those found in theoretical reasoning), but are distinctively practical, in that they involve reference to reasons for acting and to expressions of intention, respectively.1. (shrink)

Conceptual engineering is commonly characterized as the method for assessing and improving our representational devices. Little has been said, however, on how best to construe these representational devices—in other words, on what conceptual engineering should be all about. This paper tackles this problem with a basic strategy: First, by presenting a taxonomy of the different possible subject matters for conceptual engineering; then, by comparatively assessing them and selecting the most conducive one with a view to making conceptual engineering an actionable (...) method, that is, a method that can be applied effectively and consistently to specific case studies. The outcome is that conceptual engineering should be all about concepts on pain of pragmatic inconsistencies otherwise. (shrink)

As systems based on opaque Artificial Intelligence (AI) continue to flourish in diverse real-world applications, understanding these black box models has become paramount. In response, Explainable AI (XAI) has emerged as a field of research with practical and ethical benefits across various domains. This paper not only highlights the advancements in XAI and its application in real-world scenarios but also addresses the ongoing challenges within XAI, emphasizing the need for broader perspectives and collaborative efforts. We bring together experts from diverse (...) fields to identify open problems, striving to synchronize research agendas and accelerate XAI in practical applications. By fostering collaborative discussion and interdisciplinary cooperation, we aim to propel XAI forward, contributing to its continued success. Our goal is to put forward a comprehensive proposal for advancing XAI. To achieve this goal, we present a manifesto of 27 open problems categorized into nine categories. These challenges encapsulate the complexities and nuances of XAI and offer a road map for future research. For each problem, we provide promising research directions in the hope of harnessing the collective intelligence of interested stakeholders. (shrink)

This is an introductory handbook for some of the main themes around the notion of predication in Aristotle. It does not aim at being exhaustive, but only sketches some important lines about the subject; it contains an introductory essay, besides the translation (into Portuguese) and commentary of basic texts (such as Posterior Analytics I-22, Categories 1-5, Interpretation 1-6 etc.).

The value of testimony as a source of knowledge has been a subject of epistemological debates. The "trust theory of testimony" suggests that human testimony is based on an affective relationship supported by social norms. However, the advent of generative artificial intelligence challenges our understanding of genuine testimony. The concept of "quasi-testimony" seeks to characterize utterances produced by non-human entities that mimic testimony but lack certain fundamental attributes. This article analyzes these issues in depth, exploring philosophical perspectives on testimony and (...) the implications of conversational AI technologies on our epistemic practices. (shrink)

Conceptual engineering is the method for assessing and improving our concepts. Some have recently claimed that the implementation of such method in the form of ameliorative projects is truth-driven and should thus be epistemically constrained, ultimately at least (Simion 2018; cf. Podosky 2018). This paper challenges that claim on the assumption of a social constructionist analysis of ideologies, and provides an alternative, pragmatic and cognitive framework for determining the legitimacy of ameliorative conceptual projects overall. The upshot is that one should (...) not ameliorate for the sake of truth or knowledge, in the case of ideologies—at least, not primarily. (shrink)

Conceptual engineering is the method for assessing and improving our representational devices. On its ‘broad-spectrum’ version, it is expected to be appropriately applicable to any of our representation-involving cognitive activities, with major consequences for our whole cognitive life. This paper is about the theoretical foundations of conceptual engineering thus characterised. With a view to ensuring the actionability of conceptual engineering as a broad-spectrum method, it addresses the issue of how best to construe the subject matter of conceptual engineering and successively (...) defends the theses that conceptual engineering should be: (i) About concepts, (ii) psychologically theorised, (iii) as multiply realised functional kinds. Thereby, I claim to theoretically secure and justify the maximum scope, flexibility, and impact for the method of conceptual engineering on our representational devices in our whole cognitive life—in other words, a broad-spectrum version of conceptual engineering. (shrink)

This book discusses Aristotle’s notions of essence and substance as they are developed in Metaphysics ZH. I examine Aristotle's argument at length and defends an unorthodox interpretation according to which his motivation is to provide an answer against a conflation between criteria for existential priority (delivering substances as primary beings) and criteria for explanatory priority (delivering essences as primary principles).

We present an inferentialist account of the epistemic modal operator might. Our starting point is the bilateralist programme. A bilateralist explains the operator not in terms of the speech act of rejection ; we explain the operator might in terms of weak assertion, a speech act whose existence we argue for on the basis of linguistic evidence. We show that our account of might provides a solution to certain well-known puzzles about the semantics of modal vocabulary whilst retaining classical logic. (...) This demonstrates that an inferentialist approach to meaning can be successfully extended beyond the core logical constants. (shrink)

In Posterior Analytics 71b9 12, we find Aristotle’s definition of scientific knowledge. The definiens is taken to have only two informative parts: scientific knowledge must be knowledge of the cause and its object must be necessary. However, there is also a contrast between the definiendum and a sophistic way of knowing, which is marked by the expression “kata sumbebekos”. Not much attention has been paid to this contrast. In this paper, I discuss Aristotle’s definition paying due attention to this contrast (...) and to the way it interacts with the two conditions presented in the definiens. I claim that the “necessity” condition ammounts to explanatory appropriateness of the cause. (shrink)

Paul Feyerabend, one of the most original and nonconformist epistemologists of the 20th century, is known for describing science as an essentially anarchic enterprise characterized by different, sometimes contradictory, methods, approaches and ways of reasoning. But it was through his reflections on art and myth that he developed an even more radical view: there are different forms of human thought, each characterized by a different rationality and reality, and science is only one of them. And in intellectual history there is (...) only change, but not progress. (shrink)

In this paper, I discuss whether there are genuinely *diachronic* constraints of practical rationality, that is, pressures on combinations of practical attitudes over time, which are not reducible to mere synchronic rational pressures. Michael Bratman has recently argued that there is at least one such diachronic rational constraint that governs the stability of intentions over time. *Pace* Bratman, I argue that there are no genuinely diachronic constraints on intentions that meet the stringent desiderata set by him. But I show that (...) there are at least two synchronic rational constraints with distinctive and important, although only indirect, diachronic dimensions. Neither of them, however, supports the practical conservatism in the face of normative underdetermination that, according to Bratman, is part and parcel of the diachronic rationality of intention stability. (shrink)

In this paper, we develop an impure somatic theory of emotion, according to which emotions are constituted by the integration of bodily perceptions with representations of external objects, events, or states of affairs. We put forward our theory by contrasting it with Prinz's pure somatic theory, according to which emotions are entirely constituted by bodily perceptions. After illustrating Prinz's theory and discussing the evidence in its favor, we show that it is beset by serious problems—i.e., it gets the neural correlates (...) of emotion wrong, it isn't able to distinguish emotions from bodily perceptions that aren't emotions, it cannot account for emotions being directed towards particular objects, and it mischaracterizes emotion phenomenology. We argue that our theory accounts for the empirical evidence considered by Prinz and solves the problems faced by his theory. In particular, we maintain that our theory gives a unified and principled account of the relation between emotions and bodily perceptions, the intentionality of emotions, and emotion phenomenology. (shrink)

It is often argued that future-directed decisions are effective at shaping our future conduct because they give rise, at the time of action, to a decisive reason to act as originally decided. In this paper, I argue that standard accounts of decision-based reasons are unsatisfactory. For they focus either on tie-breaking scenarios or cases of self-directed distal manipulation. I argue that future-directed decisions are better understood as tools for the non-manipulative, intrapersonal division of deliberative labor over time. A future-directed decision (...) to ϕ gives rise to a defeasible exclusionary reason to ϕ. This reason is grounded on the default authority that is normally granted to one’s prior self as an “expert” deliberator. I argue that this kind of exclusionary reason is the only one that can account for the effectiveness of future-directed decisions at shaping our diachronic agency without violating our autonomy over time. (shrink)

According to Jim Pryor’s dogmatism, when you have an experience with content p, you often have prima facie justification for believing p that doesn’t rest on your independent justification for believing any proposition. Although dogmatism has an intuitive appeal and seems to have an antisceptical bite, it has been targeted by various objections. This paper principally aims to answer the objections by Roger White according to which dogmatism is inconsistent with the Bayesian account of how evidence affects our rational credences. (...) If this were true, the rational acceptability of dogmatism would be seriously questionable. I respond that these objections don’t get off the ground because they assume that our experiences and our introspective beliefs that we have experiences have the same evidential force, whereas the dogmatist is uncommitted to this assumption. I also consider the question whether dogmatism has an antisceptical bite. I suggest that the answer turns on whether or not the Bayesian can determine the priors of hypotheses and conjectures on the grounds of their extra-empirical virtues. If the Bayesian can do so, the thesis that dogmatism has an antisceptical bite is probably false. (shrink)

Translation of Aristotle’s Metaphysics IX and X (Theta & Iota) into Portuguese, with a few notes, experimental glossary and introduction. The translation, which was made at 2004, is preliminary and its publication was intended to provide a didactic tool for courses as well as a provisional resource in research seminars. It needs some revision. I am currently working (slowly...) on the revision of the translation and a new revised one will surely appear at some point.

I discuss what Aristotle means when he say that scientific demonstration must proceed from necessary principles. I argue that, for Aristotle, scientific demonstration should not be reduced to sound deduction with necessary premises. Scientific demonstration ultimately depends on the fully appropriate explanatory factor for a given explanandum. This explanatory factor is what makes the explanandum what it is. Consequently, this factor is also unique. When Aristotle says that demonstration must proceed from necessary principles, he means that each demonstration requires the (...) principle that is the necessary one for the fully appropriate explanation of its explanandum. This picture also provides a key to understand Aristotle's thesis that scientific explanation depends on essences: it is the essence of the attribute to be explained that should be stated as the fully appropriate explanatory factor. (shrink)

We develop a novel solution to the negation version of the Frege-Geach problem by taking up recent insights from the bilateral programme in logic. Bilateralists derive the meaning of negation from a primitive *B-type* inconsistency involving the attitudes of assent and dissent. Some may demand an explanation of this inconsistency in simpler terms, but we argue that bilateralism’s assumptions are no less explanatory than those of *A-type* semantics that only require a single primitive attitude, but must stipulate inconsistency elsewhere. Based (...) on these insights, we develop a version of B-type expressivism called *inferential expressivism*. This is a novel semantic framework that characterises meanings by inferential roles that define which *attitudes* one can *infer* from the use of terms. We apply this framework to normative vocabulary, thereby solving the Frege-Geach problem generally and comprehensively. Our account moreover includes a semantics for epistemic modals, thereby also explaining normative terms under epistemic modals. (shrink)

This paper discusses some issues concerning the definition of moral virtue in Nicomachean Ethics 1106b 36- 1107a 2. It is reasonable to expect from a definition the complete enumeration of the relevant features of its definiendum, but the definition of moral virtue seems to fail in doing this task. One might be tempted to infer that this definition is intended by Aristotle as a mere preliminary account that should be replaced by a more precise one. The context of the argument (...) Aristotle develops in Book II of his NE give us some help. I argue that the definition of moral virtue, once considered in the light of its context, is far from being an incomplete and provisional account: it rather introduces coherently the same notion of moral virtue that Aristotle employs in other texts (as in Nicomachean Ethics VI 13). My main proposal is that the way in which "hexis" is understood in the context of previous chapters allows Aristotle to encode in it the notion of an ability to do the right things regularly. Thus, moral virtue is a "hexis prohairetike etc.", but the ability to do the right things regularly is already encoded in the occurrence of "hexis" in the definiens account of moral virtue, as if Aristotle meant "hexis [praktike] prohairetike". (shrink)

I discuss in this paper Aristotle’s definition of nature in Physics 192b 20-23. I intend to prove that this definition has to be taken as a set of three (not only two) conditions: the first condition just establishes that nature is a sort of cause; the second condition concerns the relationship between nature and the natural thing that has it as a cause; the third condition concerns the relationship between nature and the properties that natural things have from nature’s causality.

These are commentaries to the translation into Portuguese of Nicomachean Ethics VI, found in the same volume of Dissertatio.

Electrical brain activity modulation in terms of changes in its intensity and spatial distribution is a function of age and task demand. However, the dynamics of brain modulation is unknown when it depends on external factors such as training. The aim of this research is to verify the effect of deductive reasoning training on the modulation in the brain activity of healthy younger and older adults ( (mean age of 21 ± 3.39) and (mean age of 68.92 ± 5.72)). The (...) analysis reveals the benefits of training, showing that it lowers cerebral activation while increasing the number of correct responses in the trained reasoning task (). The brain source generators were identified by time-averaging low-resolution brain electromagnetic tomography (sLORETA) current density images. In both groups, a bilateral overactivation associated with the task and not with age was identified. However, while the profile of bilateral activation in younger adults was symmetrical in anterior areas, in the older ones, the profile was located asymmetrically in anterior and posterior areas. Consequently, bilaterality may be a marker of how the brain adapts to maintain cognitive function in demanding tasks in both age groups. However, the differential bilateral locations across age groups indicate that the tendency to brain modulation is determined by age. (shrink)

Translation of Aristotle's Posterior Analytics I into Portuguese, with a few notes, experimental glossary and introduction. The translation, which was made at 2003/4, was preliminary and its publication was intended to provide a didactic tool for courses as well as a provisional resource in research seminars. It needs some revision. I am currently working (slowly...) on the revision of the translation and a new revised one will surely appear at some point.

El Anti-Excepcionalismo Lógico afirma que la Lógica es como cualquier otra ciencia. Si esta afirmación es cierta, entonces ella no sólo es revisable, sino que además todo lo que se puede decir sobre las ciencias aplica, mutatis mutandis, para la misma. El propósito de este artículo es explorar esta consecuencia del Anti-Excepcionalismo Lógico, acercando a la Filosofía de la Lógica el marco teórico de las Máquinas Nomológicas de Nancy Cartwright. De acuerdo con esta visión, lo que hay de verdadero en (...) las teorías científicas no está en el mundo sino en sus modelos: sistemas altamente controlados, estables, artificiales y específicos, dentro de los cuales se manifiestan regularidades sistematizables y enseñables. Mi afirmación es que lo mismo puede decirse de la Lógica: ella no captura las Leyes del Pensamiento o de la Razón, porque el pensamiento y la razón no están gobernados necesariamente por leyes. Sobre lo que sí puede decirse que versan las Leyes de la Lógica son metafísicas posibles: historias acerca de qué son las proposiciones, el pensamiento, la verdad y la validez. A fin de ilustrar y defender esta tesis, presento un ejemplo de Máquina Nomológica de la Lógica Clásica, basada en una lectura original del Tractatus de Wittgenstein, e investigo algunas de sus consecuencias. Mi conclusión es que esta imagen de la Lógica impacta en el problema de la revisión de la Lógica Clásica, en la medida en que muestra que dicha revisión no necesariamente responde a un proceso racional de adecuación de la teoría a los hechos porque los “hechos” relevantes no son anteriores a la teoría misma, sino que están moldeados y conducidos por ella. Palabras clave: Anti-Excepcionalismo Lógico, Abductivismo, Máquinas Nomológicas, Revisión Lógica, Filosofía de la Lógica. (shrink)

Tradução para o Português de Ethica Nicomachea VI.

Constitutivism argues that the source of the categorical force of the norms of rationality and morality lies in the constitutive features of agency. A systematic failure to be guided by these norms would amount to a loss or lack of agency. Since we cannot but be agents, we cannot but be unconditionally guided by these norms. The constitutivist strategy has been challenged by David Enoch. He argues that our participation in agency is optional and thus cannot be a source of (...) categorical demands. In this paper, I defend the viability of constitutivism by showing that agency is indeed a special ‘inescapable’ enterprise. Agency has the largest jurisdiction, and it is closed under rational assessment. This inescapability does not exempt constitutivism from raising the question whether agents have reason to be agents, but this question has to be taken up within agency. If this question is answered affirmatively, then—I argue—the criteria of practical correctness are self-ratifying in a non-circular way. This is sufficient to show the viability of the constitutivist strategy. Whether agents have conclusive reasons to be agents, however, is a matter to be addressed in the terms of particular versions of constitutivism. (shrink)

Translation of Aristotle's Metaphysics IV and VI, with notes. The translation is preliminary and intended as a provisional teaching tool to be also used in seminars and discussions with peers in order to reach a more elaborated version.

I have two aims in this paper. First, I argue that, in Aristotle’s theory of the four causes, there is a basic and common feature by which all causes are causes: they all work in a triadic framework in which they explain why a given attribute holds of a given underlying thing. Secondly, I argue against a version of “compatibilism” according to which each kind of cause is complete in its own domain and does not compete with any other kind. (...) I claim that there are priority relations according to which some kinds of cause are subordinated to others, even if these relations do not hold in every cases. (shrink)

In this paper, I will discuss the various ways in which intentions can be said to be conditional, with particular attention to the internal conditions on the intentions’ content. I will first consider what it takes to carry out a conditional intention. I will then discuss how the distinctive norms of intention apply to conditional intentions and whether conditional intentions are a weaker sort of commitments than the unconditional ones. This discussion will lead to the idea of what I call (...) the ‘deep structure’ of intentions. Roughly, this is the idea that the conditional nature of our intentions is only partially made explicit in the expressions we use to communicate our intentions and in the explicit form of our thinking about and reasoning with them. Most conditions that qualify our intentions are part of a deep functional structure that can be evinced by observing the actual psychological functioning of intentions and by considering the rational requirements that they engage. I will argue that the deep structure of intentions is characteristically conditional. Genuinely unconditional intentions are only limiting instances of conditional intentions and their contribution to agency can only be understood in light of this fact. I will conclude by showing that the characteristic conditional structure of intentions is intimately related to distinctive features of human agency, especially to its unity over time. (shrink)

The truth of a statement depends on the world in two ways: what the statement says is true if the world is as the statement says it is; on the other hand, what the expressions in the statement mean depends on what the world is like (for instance, on what conventions are in place). Each of these two kinds of dependence of truth on the world corresponds to one of the dimensions on the two-dimensional semantic framework, developed in the 1970’ (...) in the work of Evans, Kaplan, Kripke and Stalnaker. The introduction provides a systematic overview of the framework, the ideas of its earlier originators, recent developments and criticism. Finally, it gives a brief overview over the contributions to the volume. (shrink)